GeneGuessr - a daily biology web puzzle
Can you identify the protein from its 3D structure? A daily guessing game where you use clues about domains, pathways, and molecular functions to figure out which gene made the protein.
Quick read
A daily web puzzle that challenges you to identify a protein from its 3D structure using clues about domains, pathways, and functions. Visit to play a guessing game, reveal hints, and get feedback on how close your guesses are.
- Search for any gene and submit it as a guess
- Reveal or buy spoiler hints to learn about the protein
- Get feedback percentage and highlighted matching properties
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A closer look at GeneGuessr - a daily biology web puzzle
Daily protein guessing from a 3D structure
GeneGuessr presents one protein each day and asks you to identify which gene produced it from its 3D structure. The game gives clues about domains, pathways, and molecular functions to help you guess.
How you play and what the interface shows
You can search for a specific gene and submit it as your first guess. Each guess creates a feedback card and a feedback bar that shows a percentage for how close you were.
Properties that match the daily target are highlighted on feedback cards. The page uses spoiler bars that hide additional hints; tapping a spoiler reveals the hint but costs 1 hint to remove.
Guessing limits and hint rules
You get +1 hint for each guess you make. Some spoiler bars are locked when a hint would be too obvious, and you are encouraged to try unlocking a different hint.
The game allows up to 10 guesses before it ends, so you can experiment across multiple attempts.
Who will find this useful
People comfortable reading protein structures and interpreting domain, pathway, or molecular function clues will get the most out of it. It is aimed at users who enjoy technical, biology-focused puzzles rather than casual trivia.
Questions people ask about GeneGuessr - a daily biology web puzzle
- Can I look up a specific gene?
- Yes - there is a search bar where you can look up a gene and submit it as your first guess.
- How many guesses do I get?
- You get up to 10 guesses before the game ends.
- How do hints and spoiler bars work?
- Tapping a spoiler reveals a hint but costs 1 hint; you earn +1 hint for each guess and some spoilers stay locked if the hint would be too obvious.
GeneGuessr - a daily biology web puzzle was shared on NexURLs by Nexis on October 31, 2026, in Fun & Games.
What we found on this site
- Served through
- Cloudflare
- Home page answered in
- 210 ms
- Trackers
- None found
- Ads
- None found
- RSS feed
- No
- AI crawlers
- Lets them in
- Set up for phones
- Yes
- Real-visitor speed
- Not enough visitors for Google data
- Popularity
- Top 200,000 domain (Cloudflare)
- Google safety check
- No threats found
- Domain registered
- 2025
- Domain renews
- September 2027
Checked November 1, 2026 from the site’s own code and public records. See how the rest of the web compares in the NexURLs Internet Report.
Quick answers
What is GeneGuessr?
GeneGuessr (geneguessr.brinedew.bio): A daily web puzzle that challenges you to identify a protein from its 3D structure using clues about domains, pathways, and functions. Visit to play a guessing game, reveal hints, and get feedback on how close your guesses are.
Who shared GeneGuessr on NexURLs?
It was shared by Nexis in October 2026. Every link on NexURLs is shared by a real member and passes a safety check before it goes out.
What are some sites like GeneGuessr?
Members found these close to it: Foldit, Guess The Game, Metazooa. The full list is on this page under Sites like GeneGuessr.
Sites like GeneGuessr
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