Cold Triggers a Hidden Molecular Pathway That Extends Lifespan, Study Finds
Cold exposure appears to trigger a hidden molecular pathway linked to longer lifespan in animals, a study finds. Researchers identified a molecule produced in muscle that may help explain this effect, though implications for humans require more research.
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This article summarizes a Nature study showing that mild cold triggers production of the metabolite BH2 in muscle, which is converted to BH4 in other tissues and helps maintain protein homeostasis and extend lifespan in nematode worms. Researchers also showed BH2 or boosting the pathway can reduce harmful protein aggregation in human cell models, suggesting potential routes to mimic cold's benefit
- Cold raises BH2 production in muscle, promoting organism-wide proteostasis
- Boosting CAT-4 or BH2 extends worm lifespan even at warm temperatures
- BH2 reduced protein aggregation in human cell models of neurodegeneration
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Cold Triggers a Hidden Molecular Pathway That Extends Lifespan, Study Finds was shared on NexURLs on October 29, 2026, in News. So far it has 1 like, 1 comment from members.
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Cold Triggers a Hidden Molecular Pathway That Extends Lifespan, Study Finds (sciencealert.com): This article summarizes a Nature study showing that mild cold triggers production of the metabolite BH2 in muscle, which is converted to BH4 in other tissues and helps maintain protein homeostasis and extend lifespan in nematode worms. Researchers also showed BH2 or boosting the pathway can reduce...
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